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Originally posted by lamphun View PostIvermectin for Prevention and Treatment of COVID-19 Infection
A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.
We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection.
Meta-analysis of 15 trials found that ivermectin reduced risk of death compared with no ivermectin (average risk ratio 0.38, 95% confidence interval 0.19–0.73; n = 2438; I2 = 49%; moderate-certainty evidence). This result was confirmed in a trial sequential analysis using the same DerSimonian–Laird method that underpinned the unadjusted analysis. This was also robust against a trial sequential analysis using the Biggerstaff–Tweedie method. Low-certainty evidence found that ivermectin prophylaxis reduced COVID-19 infection by an average 86% (95% confidence interval 79%–91%). Secondary outcomes provided less certain evidence. Low-certainty evidence suggested that there may be no benefit with ivermectin for “need for mechanical ventilation,” whereas effect estimates for “improvement” and “deterioration” clearly favored ivermectin use. Severe adverse events were rare among treatment trials and evidence of no difference was assessed as low certainty. Evidence on other secondary outcomes was very low certainty.
Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.
Keep your friends close and your enemies closer
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31 deaths, 4,108 new infections push Thailand’s virus toll well beyond 200k
Originally posted by Somchai Boonporn View PostPerhaps a blessing in disguise for the Golden Land.
Thailand’s daily Covid-19 caseload rose to 4,108 infections and 31 deaths over the past 24 hours on Thursday.
Of the total cases, 2,835 tested positive in hospitals, 1,030 were found via proactive testing, 229 were found in prisons and 14 were arrivals from overseas.
Bangkok topped the list with 1,359 cases, followed by Samut Prakan (297), Samut Sakhon (259), Chonburi (254), Songkhla (216), Nonthaburi (170), Pathum Thani (157) and Yala (119).
Meanwhile, 1,578 patients have recovered and been discharged in the last 24 hours.
Thailand’s accumulated infections rose to 232,647 on Thursday. Of these, 191,355 have recovered, 39,517 are still in hospital, and 1,775 have died.
Meanwhile, the last 24 hours saw another 172,903 people being given their first Covid-19 shot, while 79,082 people got their second shot. This brings the total number of doses administered in Thailand to 8,400,320.: https://www.nationthailand.com/in-focus/40002415
Originally posted by Somchai Boonporn View PostPerhaps a blessing in disguise for the Golden Land.
Keep your friends close and your enemies closer
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